HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Cyanopyridine-2-carboxylic acid → (S)-N-(2-Chloro-4-(morpholin-2-yl)phenyl)-5-cyanopicolinamide hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Cyanopyridine-2-carboxylic acid | HCID 12400734 | — |
| Reactant | (S)-tert-butyl 2-(4-amino-3-chlorophenyl)morpholine-4-carboxylate | HCID 68325446 | — |
| Product | (S)-N-(2-Chloro-4-(morpholin-2-yl)phenyl)-5-cyanopicolinamide hydrochloride | HCID 71087349 | — |
Reaction Steps
In analogy to example 79, step a) using 5-cyano-2-pyridinecarboxylic acid (CAS 53234-55-2) instead of 4-cyanopicolinic acid (CAS 640296-19-1) and (−)-(S)-2-(4-Amino-3-chloro-phenyl)-morpholine-4-carboxylic acid tert-butyl ester (example 29a) instead of (−)-(S)-2-(4-Amino-3-fluoro-phenyl)-morpholine-4-carboxylic acid tert-butyl ester. White solid. MS (ISP): 341.1 ([M+H]+)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09029370B2 |
| Source dataset | uspto-grants-2015_05 |
| ORD ID | ord-de01b6416f084ad18b14abdd34a69303 |
| Source note | uspto-grants-2015_05 |