5-Cyanopyridine-2-carboxylic acid → (R)-N-(2-Chloro-4-(morpholin-2-yl)phenyl)-5-cyanopicolinamide hydrochloride

Participants

Reaction Steps

In analogy to example 79, step a) using 5-cyano-2-pyridinecarboxylic acid (CAS 53234-55-2) instead of 4-cyanopicolinic acid (CAS 640296-19-1) and (+)-(R)-2-(4-Amino-3-chloro-phenyl)-morpholine-4-carboxylic acid tert-butyl ester (example 29a) instead of (−)-(S)-2-(4-Amino-3-fluoro-phenyl)-morpholine-4-carboxylic acid tert-butyl ester. White solid. MS (ISP): 341.1 ([M+H]+)

Provenance & Evidence