2-(Trifluoromethyl)pyridine-4-carboxylic acid → (S)-N-(2-Chloro-4-(morpholin-2-yl)phenyl)-1-(4-cyanophenyl)-1H-pyrazole-4-carboxamide hydrochloride

Participants

Role	Name	HCID	Charge
Reactant	2-(Trifluoromethyl)pyridine-4-carboxylic acid	HCID 14761447	—
Reactant	1-(4-Cyanophenyl)-1H-pyrazole-4-carboxylic acid	HCID 43259425	—
Reactant	(S)-tert-butyl 2-(4-amino-3-chlorophenyl)morpholine-4-carboxylate	HCID 68325446	—
Product	(S)-N-(2-Chloro-4-(morpholin-2-yl)phenyl)-1-(4-cyanophenyl)-1H-pyrazole-4-carboxamide hydrochloride	HCID 71086869	—

Reaction Steps

In analogy to example 83, step a) using 1-(4-cyanophenyl)-1H-Pyrazole-4-carboxylic acid (CAS 1152945-21-5)) instead of 2-(trifluoromethyl)-4-pyridinecarboxylic acid (CAS 131747-41-6) and (−)-(S)-2-(4-Amino-3-chloro-phenyl)-morpholine-4-carboxylic acid tert-butyl ester (example 29a) instead of (+)-(R)-2-(4-Amino-2-fluoro-phenyl)-morpholine-4-carboxylic acid tert-butyl ester. White solid. MS (ISP): 408.2 ([M+H]+)

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09029370B2
Source dataset	uspto-grants-2015_05
ORD ID	ord-69103bb4c3384b87955445e8dbabdcde
Source note	uspto-grants-2015_05