(S)-tert-Butyl 2-(4-amino-3-fluorophenyl)morpholine-4-carboxylate → (S)-4-Chloro-6-cyano-N-(2-fluoro-4-(morpholin-2-yl)phenyl)picolinamide hydrochloride

Participants

Reaction Steps

In analogy to Example 83, step a) using 4-chloro-6-cyano-2-pyridine carboxylic acid (CAS 1060812-13-6) instead of 2-(trifluoromethyl)-4-pyridinecarboxylic acid (CAS 131747-41-6) and (−)-(S)-2-(4-Amino-3-fluoro-phenyl)-morpholine-4-carboxylic acid tert-butyl ester (example 1 step h) instead of (+)-(R)-2-(4-Amino-2-fluoro-phenyl)-morpholine-4-carboxylic acid tert-butyl ester. White solid. MS (ISP): 359.1 ([M+H]+)

Provenance & Evidence