HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 571869Generated: October 26, 2026
Dimethylformamide → Methyl 2-cyano-6-methoxyisonicotinate
https://huagongshe.com/reaction/571869
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Methyl 2-chloro-6-methoxyisonicotinate | HCID 13339618 | — |
| Catalyst | Zinc cyanide (Zn(CN)2) | HCID 11186 | — |
| Product | Methyl 2-cyano-6-methoxyisonicotinate | HCID 11252506 | — |
Reaction Steps
Under N2, methyl 2-chloro-6-methoxyisonicotinate (CAS 42521-10-8) (3.97 g, 19.7 mmol, Eq: 1.00), zinc cyanide (2.77 g, 23.6 mmol, Eq: 1.2) and Tetrakis-triphenylphosphin-palladium (1.14 g, 985 μmol, Eq: 0.05) were mixed in DMF (67.5 ml). The RM was stirred under microwave at 160° C. for 30 minutes. Control with LC-MS: the reaction was finished.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09029370B2 |
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| Source dataset | uspto-grants-2015_05 |
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| ORD ID | ord-99f0653e292a4eeab516486adb003f18 |
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| Source note | uspto-grants-2015_05 |
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