(S)-tert-butyl 2-(4-amino-3-chlorophenyl)morpholine-4-carboxylate → (S)-N-(2-Chloro-4-(morpholin-2-yl)phenyl)-2-cyano-6-methoxyisonicotinamide hydrochloride

Participants

Reaction Steps

In analogy to example 83, step a) using 2-Cyano-6-methoxy-isonicotinic acid (described in example 107) instead of 2-(trifluoromethyl)-4-pyridinecarboxylic acid (CAS 131747-41-6) and (−)-(S)-2-(4-Amino-3-chloro-phenyl)-morpholine-4-carboxylic acid tert-butyl ester (described in example 29a) instead of (+)-(R)-2-(4-Amino-2-fluoro-phenyl)-morpholine-4-carboxylic acid tert-butyl ester.

Provenance & Evidence