4-Chloro-6-cyanopicolinic acid → (S)-4-Chloro-6-cyano-N-(3-fluoro-4-(morpholin-2-yl)phenyl)picolinamide hydrochloride

Participants

Reaction Steps

In analogy to example 83, step a) using 4-chloro-6-cyano-2-pyridine carboxylic acid (CAS 1060812-13-6) instead of 2-(trifluoromethyl)-4-pyridinecarboxylic acid (CAS 131747-41-6) and (−)-(S)-2-(4-Amino-2-fluoro-phenyl)-morpholine-4-carboxylic acid tert-butyl ester (described in example 83) instead of (+)-(R)-2-(4-Amino-2-fluoro-phenyl)-morpholine-4-carboxylic acid tert-butyl ester.

Provenance & Evidence