HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dioxindole → 3-Amino-3-(2-ethoxypyridin-3-yl)-6-fluoro-1-(4-methoxyphenylsulfonyl)-2-oxo-2,3-dihydro-1H-indole-5-carbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dioxindole | HCID 6097 | — |
| Reactant | 4-Methoxybenzenesulfonyl chloride | HCID 7401 | — |
| Reactant | Sulfuryl chloride | HCID 24648 | — |
| Reactant | 3-(2-ethoxypyridin-3-yl)-6-fluoro-3-hydroxy-2-oxo-2,3-dihydro-1H-indole-5-carbonitrile | HCID 67087458 | — |
| Product | 3-Amino-3-(2-ethoxypyridin-3-yl)-6-fluoro-1-(4-methoxyphenylsulfonyl)-2-oxo-2,3-dihydro-1H-indole-5-carbonitrile | HCID 67087801 | — |
Reaction Steps
The title compound was prepared using 3-(2-ethoxypyridin-3-yl)-6-fluoro-3-hydroxy-2-oxo-2,3-dihydro-1H-indole-5-carbonitrile as 3-hydroxy-1,3-dihydroindol-2-one IV and 4-methoxyphenylsulfonyl chloride as sulfonyl chloride VII in analogy to example 1.1 to 1.3.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09434713B2 |
| Source dataset | uspto-grants-2016_09 |
| ORD ID | ord-b184195785ec4a2eb14924203036e5f4 |
| Source note | uspto-grants-2016_09 |