Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Dioxindole → 3-Amino-5-chloro-1-(2,4-dimethoxyphenylsulfonyl)-3-(2-ethoxypyridin-3-yl)-6-fluoro-1,3-dihydroindol-2-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Dioxindole | HCID 6097 | — |
| 반응물 | Sulfuryl chloride | HCID 24648 | — |
| 반응물 | 2,4-Dimethoxybenzenesulfonyl chloride | HCID 2734626 | — |
| 반응물 | HCID 67087479 | HCID 67087479 | — |
| 생성물 | 3-Amino-5-chloro-1-(2,4-dimethoxyphenylsulfonyl)-3-(2-ethoxypyridin-3-yl)-6-fluoro-1,3-dihydroindol-2-one | HCID 67087429 | — |
| 생성물 | HCID 67087479 | HCID 67087479 | — |
반응 단계
3-Amino-5-chloro-1-(2,4-dimethoxyphenylsulfonyl)-3-(2-ethoxypyridin-3-yl)-6-fluoro-1,3-dihydroindol-2-one was prepared in analogy to example 1.1 to 1.3 using 5-chloro-3-(2-ethoxypyridin-3-yl)-6-fluoro-3-hydroxy-1,3-dihydroindol-2-one as 3-hydroxy-1,3-dihydroindol-2-one IV and 2,4-dimethoxyphenylsulfonyl chloride as sulfonyl chloride VII. 5-Chloro-3-(2-ethoxypyridin-3-yl)-6-fluoro-3-hydroxy-1,3-dihydroindol-2-one was prepared in analogy to example a.1.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09434713B2 |
| 출처 데이터셋 | uspto-grants-2016_09 |
| ORD ID | ord-e3e9d81bc0c74326998525d33caf09df |
| 출처 메모 | uspto-grants-2016_09 |