反应详情

1H-Pyrazolo[3,4-b]pyridin-5-amine (B) (212 mg, 1.58 mmol) was dissolved in acetonitrile. To the reaction mixture was added pyridine (0.15 mL, 1.896 mmol) and phenyl chloroformate (0.2 mL, 1.659 mmol) and stirred at room temperature for 30 min under N2. TLC showed complete consumption of starting material. The reaction mixture was diluted with water and extracted with ethyl acetate. The organic part was washed with water and brine. The organic layer was dried over MgSO4 and concentrated under reduced pressure. The crude was purified by column chromatography to give phenyl 1H-pyrazolo[3,4-b]pyridin-5-ylcarbamate (C). (285 mg, 71%)

1. customconsumption of starting material
2. additionThe reaction mixture was diluted with water
3. extractionextracted with ethyl acetate
4. washThe organic part was washed with water and brine
5. dry with materialThe organic layer was dried over MgSO4
6. concentrationconcentrated under reduced pressure
7. customThe crude was purified by column chromatography