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Pyridine → Phenyl isoquinolin-1-ylcarbamate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Pyridine | HCID 1049 | — |
| 反応物 | Phenyl chloroformate | HCID 15891 | — |
| 反応物 | 1-Isoquinolinamine | HCID 73742 | — |
| 溶媒 | Water | HCID 962 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | Phenyl isoquinolin-1-ylcarbamate | HCID 86676325 | 52% |
反応手順
Isoquinolin-1-amine (300 mg, 2.08 mmol) was dissolved in acetonitrile. The reaction mixture was added pyridine (0.02 mL, 2.50 mmol) and phenyl chloroformate (0.27 mL, 2.18 mmol) and stirred at room temperature for 1 h. The reaction mixture was diluted with water and extracted with ethyl acetate. The organic layer was concentrated under reduced pressure. The crude was purified by column chromatography to give phenyl isoquinolin-1-ylcarbamate (285 mg, 52%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09029378B2 |
| 出典データセット | uspto-grants-2015_05 |
| ORD ID | ord-33a8d047ecd44e31990e8c3b57afeb97 |
| 出典メモ | uspto-grants-2015_05 |