HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 572123Generated: November 3, 2026
[8-Chloro-2-(pyridin-3-yl)quinolin-3-yl]methanol → 8-Chloro-2-(pyridin-3-yl)quinoline-3-carbaldehyde
https://huagongshe.com/reaction/572123
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | [8-Chloro-2-(pyridin-3-yl)quinolin-3-yl]methanol | HCID 66691162 | — |
| Catalyst | Manganese dioxide | HCID 14801 | — |
| Solvent | Chlorobenzene | HCID 7964 | — |
| Product | 8-Chloro-2-(pyridin-3-yl)quinoline-3-carbaldehyde | HCID 86701165 | 86.3% |
Reaction Steps
A mixture of [8-chloro-2-(pyridin-3-yl)quinolin-3-yl]methanol (0.6 g, 2.2 mmol) and MnO2 (1.0 g) in chlorobenzene (30 mL) was heated at 70° C. overnight, filtered through a celite plug, concentrated in vacuo and washed with DCM to give the title compound (510 mg, 86%) as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09029392B2 |
|---|
| Source dataset | uspto-grants-2015_05 |
|---|
| ORD ID | ord-bd499a79d24743db8d495e4983418023 |
|---|
| Source note | uspto-grants-2015_05 |
|---|
