1,8-Diazabicyclo(5.4.0)undec-7-ene → HCID 86701169, compound

Participants

Reaction Steps

A mixture of this material (10 g, 68.0 mmol) and PyBOP (38.9 g, 74.8 mmol) in acetonitrile (250 mL) was treated with DBU (12.2 mL, 81.6 mmol) and stirred for 2.5 h. The reaction mixture was filtered, and the precipitate was washed with diethyl ether (3×50 mL) and dried under vacuum. The title compound (13.51 g, 75%) was obtained as a cream-coloured solid. δH (DMSO-d6) 9.28 (dd, J 4.2, 1.6 Hz, 1H), 8.82 (s, 1H), 8.59 (dd, J 8.6, 1.5 Hz, 1H), 8.24-8.18 (m, 2H), 7.88-7.85 (m, 1H), 7.69-7.64 (m, 1H), 7.60-7.54 (m, 1H). LCMS (ES+) 265 (M+H)+, RT 1.23 minutes.

Provenance & Evidence