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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 572141Generated: November 1, 2026

1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide → HCID 66463259, compound

https://huagongshe.com/reaction/572141

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimideHCID 15908—
Reactant2-CyclohexylethylamineHCID 20509—
Reactant6-Bromonicotinic acidHCID 238932—
ProductHCID 66463259HCID 6646325914%

Reaction Steps

Compound 26 was obtained according to general procedure II, method A, starting from 6-bromonicotinic acid, cyclohexylethylamine (5.0 equiv.) and using EDCI (4.5 equiv.) as coupling agent. The reaction was stopped after 12 days at R.T. and 12 Hrs at 80° C. Purification by flash-chromatography (AcOEt 20% in cyclohexane) afforded the product in 14% yield.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09029393B2
Source datasetuspto-grants-2015_05
ORD IDord-19233e4cede24f4b826cdb8596dcae7b
Source noteuspto-grants-2015_05