Hydrochloric Acid → Imidazo(1,2-a)pyridine

Participants

Reaction Conditions

Reaction Steps

To a solution of bromo-imidazo[1,2-a]pyridine derivatives (1.0 equiv.) in DMF, Zinc cyanide (1.1 equiv.) and Pd(PPh3)4 (5%) were added under inert atmosphere. The resulting mixture was heated through microwave irradiation for 10 min at 130° C. (Power max tolerated was 70 W). The yellow cloudy reaction mixture was hydrolyzed with HCl 1N solution then extracted with Et2O. Aqueous layer was cooled by an ice bath, and NaOH solid was added until a pH was greater than 10. The resulting aqueous basic layer was extracted with EtOAC. Organic layer was washed with brine, dried over MgSO4 and concentrated under reduced pressure.

Provenance & Evidence