Formic Acid → HCID 46847213, compound

HRID 572148Notes

Reaction equation

[NH2:1][C:2]1[CH:7]=[C:6]([C:8]([N:10]2[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12][CH2:11]2)=[O:9])[CH:5]=[CH:4][C:3]=1[C:17]([C:19]1[N:23]2[CH:24]=[C:25]([F:28])[CH:26]=[CH:27][C:22]2=[N:21][CH:20]=1)=O.C(O)=O.[CH:32]([NH2:34])=O>>[N:10]1([C:8]([C:6]2[CH:7]=[C:2]3[C:3]([C:17]([C:19]4[N:23]5[CH:24]=[C:25]([F:28])[CH:26]=[CH:27][C:22]5=[N:21][CH:20]=4)=[N:34][CH:32]=[N:1]3)=[CH:4][CH:5]=2)=[O:9])[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12][CH2:11]1

Participants

Reactant 3

HCID 284Formic Acid

HCID 713Formamide

HCID 46846870HCID 46846870, compound

Product 1

HCID 46847213HCID 46847213, compound

Conditions

Temperature: 170 °C

Procedure

A solution of example 30 (50 mg) in a mixture of formic acid (160 μL, 32 equiv.) and formamide (640 μL, 122 equiv.), under argon atmosphere, was heated through microwave irradiation for 25 min at 170° C.

Sources & evidence

ORD record: ord-060181a876b04f27a57a223ecab3a6ee
Source dataset: uspto-grants-2015_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09029393B2

Reaction notes

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