HCID 13764015, compound → HCID 13764016, compound

HRID 572162Notes

Reaction equation

HRID 572162 reaction equation
[N:1]1[CH:2]=[CH:3][N:4]2[CH:9]=[CH:8][CH:7]=[C:6]([C:10]3[CH:15]=[CH:14][C:13]([OH:16])=[CH:12][CH:11]=3)[C:5]=12>[Pd].CO>[N:1]1[CH:2]=[CH:3][N:4]2[CH2:9][CH2:8][CH2:7][CH:6]([C:10]3[CH:11]=[CH:12][C:13]([OH:16])=[CH:14][CH:15]=3)[C:5]=12

Participants

4

Reactant 1

HCID 13764015HCID 13764015, compound

Product 1

HCID 13764016HCID 13764016, compoundYield 62.4%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A mixture of 4-(imidazo[1,2-a]pyridin-8-yl)phenol (0.22 g), 10% palladium on carbon (containing water (50%), 0.10 g) and methanol (15 ml) was stirred under a hydrogen atmosphere at room temperature for 5 days. The reaction mixture was filtered, and the filtrate was concentrated under reduced pressure. The obtained solid was washed with ethyl acetate to give the title compound (0.14 g).

Workup

  1. filtrationThe reaction mixture was filtered
  2. concentrationthe filtrate was concentrated under reduced pressure
  3. washThe obtained solid was washed with ethyl acetate

Sources & evidence

ORD record
ord-6c8cd041733045f4a51bcd6e63d96df1
Source dataset
uspto-grants-2015_05
Patent number
US09029388B2

Reaction notes

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