Sulfuric Acid → HCID 86704980, compound

Participants

Reaction Steps

A mixture of 1-[4-(benzyloxy)phenyl]-2-methyl-1,2-dihydro-3H-pyrazolo[3,4-b]pyridin-3-one (0.28 g) obtained in Example 6, step D) and concentrated sulfuric acid (5.0 ml) was stirred at room temperature for 10 min. The obtained reaction mixture was diluted with water (10 ml), sodium hydroxide in m solid was added to pH 10, and the mixture was extracted with ethyl acetate. The organic layers were combined, dried over anhydrous magnesium sulfate, and the solvent was evaporated under reduced pressure. The obtained residue was purified by silica gel column chromatography (hexane/ethyl acetate) to give the title compound (0.15 g).

Provenance & Evidence