1-Isocyanatoadamantane → HCID 68281294, compound

Participants

Reaction Steps

Compound 2287 was prepared in 60% yield from adamantyl isocyanate and 4-(4-amino-phenoxy)-pyridine-2-carboxylic acid methylamide using the procedure detailed for compound 2221 in Example 4. 1H NMR (300 MHz, DMSO-d6) δ 8.73 (q, J=5 Hz, 1H), 8.48 (d, J=6 Hz, 1H), 8.39 (s, 1H), 7.49-7.42 (m, 2H), 7.36 (d, J=2 Hz, 1H), 7.13-7.03 (m, 3H), 5.89 (s, 1H), 2.78 (d, J=5 Hz, 3H), 2.09-2.01 (m, 3H), 1.98-1.92 (m, 6H), 1.68-1.60 (m, 61).

Provenance & Evidence