4-(Trifluoromethyl)phenyl isocyanate → HCID 178522059, compound

Participants

Reaction Steps

Compound 2372 was prepared in 70% yield from 4-(trifluoromethyl)phenyl isocyanate and trans-4-(4-amino-cyclohexyloxy)-benzoic acid using the procedure detailed for compound 2221 in Example 4. 1H NMR (400 MHz, DMSO-d6): δ 12.62 (s, 1H), 9.00 (s, 1H), 7.86 (d, J=9 Hz, 2H), 7.60-7.53 (m, 4H), 7.02 (d, J=9 Hz, 2H), 6.52 (d, J=8 Hz, 1H), 4.50-4.40 (m, 1H), 3.60-3.48 (m, 1H), 2.11-2.01 (m, 2H), 1.98-1.89 (m, 2H), 1.56-1.32 (m, 4H).

Provenance & Evidence