反应详情

To a suspension of (2-fluorophenyl)thiourea (1.7 g, 10.0 mmol) in chloroform (25 ml) was added a solution of bromine (0.51 mL; 10.0 mmol) dropwise at room temperature. The resulting mixture was heated under reflux for 3 hrs. The solvent was evaporated, water was added and the mixture was neutralized with ammonium hydroxide. The resulting white precipitation was collected by filtration and dried to yield 1.2 g (72%) of the title compound which was used in the subsequent step without further purification.

1. temperatureThe resulting mixture was heated
2. temperatureunder reflux for 3 hrs
3. customThe solvent was evaporated
4. additionwater was added
5. customThe resulting white precipitation
6. filtrationwas collected by filtration
7. customdried