HCID 57606110, compound → HCID 57606107, compound

Participants

Reaction Steps

Prepared from N-Methoxy-N-methyl-4-(4-methyl-5-trifluoromethyl-isoxazol-3-yl)-benzamide and tert-butylmagnesium bromide as described in Example 5. Chromatographed on silica gel with EtOAc/hexanes (5%) as eluant to afford product as a colorless solid (53 mg, 9%). 1H NMR (CDCl3) 1.37 (s, 9H), 2.29 (d, J=1.3, 3H), 7.68 (d, J=7.9, 2H), 7.81 (d, J=8.3, 2H). 19F NMR −63.2. LC/MS 7.42 min, [M+1]+ 312.

Provenance & Evidence