Acetyl chloride → HCID 25211385, compound

Participants

Reaction Steps

A suspension of ((R)-3-Amino-piperidin-1-yl)-[5-(4-methyl-5-trifluoromethyl-isoxazol-3-yl)-thiophen-2-yl]-methanone, hydrochloride (Example 27, 79 mg, 0.2 mmol) in THF (2 mL) was treated with triethylamine (70 μL, 0.5 mmol) followed by acetyl chloride (22 μL, 0.3 mmol). The reaction mixture was allowed to stir 48 hr, evaporated and chromatographed on silica gel with EtOAc then MeOH/EtOAc (10%) as eluant to afford product as a colorless solid (66 mg, 83%). 1H NMR (CDCl3) 1.65 (m, 2H), 1.81 (m, 1H), 1.95 (s, 3H), 2.00 (obs m, 1H), 2.33 (d, J=1.3, 3H), 3.30 (m, 2H), 3.98 (m, 2H), 4.10 (br d, J=11.0, 1H), 6.10 (br d, J=6.6, 1H), 7.43 (d, J=4.0, 1H), 7.49 (br s, 1H). 13C NMR 7.9, 23.5, 30.1, 46.5, 51.0 (br), 114.8, 118.7 (q, J=271), 128.3, 129.7, 131.7, 140.1, 155.2 (J=40), 157.9, 163.3, 170.3 19F NMR −63.1. LC/MS 5.72 min, [M+1]+ 402.

Provenance & Evidence