Benzoyl chloride → [5-(4-Methyl-5-trifluoromethyl-isoxazol-3-yl)-thiophen-2-yl]-phenyl-methanone

Participants

Reaction Steps

Prepared from 4-Methyl-3-thiophen-2-yl-5-trifluoromethyl-isoxazole and benzoyl chloride by the method described in Example 3. Crude product was chromatographed on silica gel with EtOAc/hexanes (10 then 20%) as eluant to afford product as a colorless solid (118 mg, 70%). 1H NMR (CDCl3) 2.33 (d, J=1.3, 3H), 7.43-7.59 (m, 4 H), 7.62 (d, J=4.0, 1H), 7.80-7.83 (m, 2H). 13C NMR 7.9, 118.7 (q, J=271), 128.8, 128.9, 129.4, 133.0, 134.8, 136.3, 137.7, 145.8, 155.5 (q, J=40), 157.9, 188.0. 19F NMR −63.1. LC/MS 7.29 min, [M+1]+ 338.

Provenance & Evidence