反应详情

To a suspension of 3-thioureidobenzoic acid (1.06 g, 5.41 mmol) in chloroform (25 mL) was added a solution of bromine (0.4 mL, 8.0 mmol) dropwise at room temperature. The resulting mixture was heated under reflux for 3 hrs and allowed to stir at room temperature for 60 hrs. The solvent was evaporated, water was added and the resulting solids were isolated by filtration. The crude product was washed with water and dried to yield 1.03 g (98%) of the title compound as a gray solid.

1. temperatureThe resulting mixture was heated
2. temperatureunder reflux for 3 hrs
3. customThe solvent was evaporated
4. additionwater was added
5. customthe resulting solids were isolated by filtration
6. washThe crude product was washed with water
7. customdried