HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 6-Bromo-5-fluorobenzo[b]thiophene-2-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Lithium Hydroxide | HCID 3939 | — |
| Reactant | Methyl 6-bromo-5-fluorobenzothiophene-2-carboxylate | HCID 70982166 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 6-Bromo-5-fluorobenzo[b]thiophene-2-carboxylic acid | HCID 70982056 | 90.9% |
Reaction Steps
Using analogous reagents and reaction conditions as described in Example 25 for the preparation of I-25b above, 6-bromo-5-fluoro-benzo[b]thiophene-2-carboxylic acid methyl ester (I-27b: 0.3 g, 1.0 mmol) in THF (10 mL) was hydrolyzed with LiOH (87 mg, 2.04 mmol) and water (2 mL) to afford 250 mg of the product (yield 88%)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09029399B2 |
| Source dataset | uspto-grants-2015_05 |
| ORD ID | ord-05605056f18444218277b12f33947421 |
| Source note | uspto-grants-2015_05 |