1-(3-Bromo-4-fluorophenylthio)propan-2-one → 6-Bromo-5-fluoro-3-methylbenzo[b]thiophene

Participants

Reaction Steps

Using analogous reagents and reaction conditions as described in Example 24 for the preparation of I-24b above, 1-(3-bromo-4-fluoro-phenylsulfanyl)-propan-2-one (I-29a: 2.1 g, 8.015 mmol) in toluene (10 mL) was cyclized with polyphosphoric acid (8 g) to yield crude product which was purified by column chromatography on silica gel (100% hexane) to afford 1.4 g of product (72% yield).

Provenance & Evidence