HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 2-(2-(Trifluoromethyl) pyridin-4-yl)-2,4-diazabicyclo[3.1.0]hexan-3-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Benzyl 3-oxo-4-(2-(trifluoromethyl)pyridin-4-yl)-2,4-diazabicyclo[3.1.0]hexane-2-carboxylate | HCID 70982114 | — |
| Product | 2-(2-(Trifluoromethyl) pyridin-4-yl)-2,4-diazabicyclo[3.1.0]hexan-3-one | HCID 70983140 | 112.8% |
Reaction Steps
Using analogous reagents and reaction conditions as described in Example 30 for the preparation of I-30c, benzyl 3-oxo-4-(2-(trifluoromethyl)pyridin-4-yl)-2,4-diazabicyclo[3.1.0]hexane-2-carboxylate (I-32a: 55 mg, 0.1458 mmol) was treated with 4.0 mL of 6N HCl to yield the 40 mg of the product (85% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09029399B2 |
| Source dataset | uspto-grants-2015_05 |
| ORD ID | ord-96ab0e688b5f454cad868f6cda4fc4d8 |
| Source note | uspto-grants-2015_05 |