HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(Trifluoromethyl)aniline → N-(2-chloroethyl)-N'-[3-(trifluoromethyl)phenyl]urea
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(Trifluoromethyl)aniline | HCID 7375 | — |
| Reactant | 2-Chloroethyl isocyanate | HCID 16035 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | N-(2-chloroethyl)-N'-[3-(trifluoromethyl)phenyl]urea | HCID 276667 | 96% |
Reaction Steps
Using analogous reagents and reaction conditions as described in Example 1 above, 3-trifluoromethyl-phenylamine (2.0 g, 12.412 mmol) in toluene (20 mL) was reacted with 1-chloro-2-isocyanatoethane (1.96 g, 18.618 mmol to give 3.2 g of pure product (96%)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09029399B2 |
| Source dataset | uspto-grants-2015_05 |
| ORD ID | ord-57c089001175415c92bcf0bd1c1b4a05 |
| Source note | uspto-grants-2015_05 |