HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → 1-[3-(Trifluoromethyl)phenyl]imidazolidin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | N-(2-chloroethyl)-N'-[3-(trifluoromethyl)phenyl]urea | HCID 276667 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 1-[3-(Trifluoromethyl)phenyl]imidazolidin-2-one | HCID 1478109 | 104.8% |
Reaction Steps
Using analogous reagents and reaction conditions as described in Example 1 above, 1-(2-chloro-ethyl)-3-(3-trifluoromethyl-phenyl)-urea (I-36a: 3.2 g, 12.02 mmol) was reacted with sodium hydride (870 mg, 18.03 mmol) in dry THF (35 mL to give 2.9 g of product (95%)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09029399B2 |
| Source dataset | uspto-grants-2015_05 |
| ORD ID | ord-d404253de3934b6894402e1fd570525c |
| Source note | uspto-grants-2015_05 |