Cesium carbonate → 1-(4-Cyclopropylpyridin-3-yl)-3-(6-methoxypyrimidin-4-yl)imidazolidin-2-one

Participants

Reaction Steps

Using analogous reagents and reaction conditions as described in Example 11 above, 1-(4-cyclopropylpyridin-3-yl)imidazolidin-2-one (I-1d: 100 mg, 0.492 mmol) was reacted with 4-chloro-6-methoxypyrimidine (78 mg, 0.541 mmol), 2-dicyclohexyl-phosphino-2′,4′,6′-triisopropylbiphenyl (23 mg, 0.0492 mmol), Pd2(dba)3 (23 mg, 0.024 mmol), cesium carbonate (400 mg, 1.23 mmol) and toluene (10 mL) in seal tube at 115° C. for 14 hours. Purification by column chromatography on silica gel (2% methanol in chloroform) afforded 50 mg of the product (34.6% yield).

Provenance & Evidence