Potassium Phosphate, Tribasic → HCID 66576816, compound

Participants

Reaction Steps

Using analogous reagents and reaction conditions as described in Example 1 above, 1-(4-cyclopropylpyridin-3-yl)imidazolidin-2-one (I-1d: 100 mg, 0.492 mmol) was reacted with 2-bromo-5-fluoro-4-methylpyridine (102 mg, 0.541 mmol) 1,4-dioxane (5 mL), copper iodide (9 mg, 0.0492 mmol), trans-N,N′-dimethylcyclohexane-1,2-diamine (21 mg, 0.147 mmol) and potassium phosphate (313 mg, 1.47 mmol) to afford the crude product. Purification by column chromatography on silica gel (80% ethyl acetate in hexane) afforded 60 mg of the product (39.21% yield).

Provenance & Evidence