Cesium carbonate → 1-(4-Cyclopropylpyridin-3-yl)-3-(2-cyclopropylpyrimidin-4-yl)imidazolidin-2-one

Participants

Reaction Steps

Using analogous reagents and reaction conditions as described in Example 11 above, 1-(4-cyclopropylpyridin-3-yl)imidazolidin-2-one (I-1d: 100 mg, 0.492 mmol) was reacted with 4-chloro-2-cyclopropylpyrimidine (I-43a: 92 mg, 0.591 mmol), 2-dicyclohexylphosphino-2′,4′,6′-triisopropylbiphenyl (24 mg, 0.0492 mmol), Pd2(dba)3 (23 mg, 0.0246 mmol), cesium carbonate (400 mg, 1.23 mmol) and toluene (5 mL) in seal tube at 110° C. for 14 hours. Purification by column chromatography on silica gel (2% methanol in chloroform), followed by preparative HPLC afforded 25 mg of the product (% yield).

Provenance & Evidence