1,2-Diaminocyclohexane, trans- → HCID 66576894, compound

Participants

Reaction Steps

Using analogous reagents and reaction conditions as described in Example 1 above, 1-(4-cyclopropylpyridin-3-yl)imidazolidin-2-one (I-1d: 500 mg, 2.4630 mmol) was reacted with 2,6-dichloro-4-iodopyridine (810 mg, 2.9556 mmol), copper iodide (47 mg, 0.2463 mmol), trans-cyclohexane-1,2-diamine (0.089 mL, 0.7389 mmol), potassium phosphate (1.56 g, 7.3891 mmol) and 1,4-dioxane (10 mL) to afford crude product. Purification by column chromatography on silica gel (2% methanol in chloroform) afforded 800 mg of pure product (93.02% yield).

Provenance & Evidence