Potassium Phosphate, Tribasic → 4-Cyclopropyl-3-(2-oxo-3-(2-(trifluoromethyl) pyridin-4-yl)imidazolidin-1-yl) pyridine 1-oxide

Participants

Reaction Steps

Using analogous reagents and reaction conditions as described in Example 1 above, 1-(3-trifluoromethyl-phenyl)-imidazolidin-2-one (I-36b: 60 mg, 0.259 mmol) was reacted with 4-cyclopropyl-3-iodopyridine 1-oxide (I-50a: 81 mg, 0.31 mmol), copper iodide (5 mg, 0.025 mmol), trans-N,N′-dimethylcyclohexane-1,2-diamine (4 mg, 0.025 mmol), potassium phosphate (165 mg, 0.77 mmol) and 1,4-dioxane (5 mL) to afford crude product. Purification by column chromatography on silica gel (1.5% methanol in chloroform) afforded 65 mg of pure product (71.4% yield).

Provenance & Evidence