反应详情

4-Cyclopropyl-3-(2-oxo-3-(2-(trifluoromethyl) pyridin-4-yl)imidazolidin-1-yl)pyridine 1-oxide (I-50b: 100 mg, 0.273 mmol) was heated with acetic anhydride (5 mL) at 120° C. for 3 hours. The resulting mixture was concentrated, basified with dilute sodium bicarbonate solution, and diluted with DCM. The organic layer was dried over sodium sulphate and concentrated to afford the crude product. Purification by column chromatography on silica gel (3% methanol in chloroform), followed by preparative HPLC afforded 8 mg of the product (8% yield).

1. concentrationThe resulting mixture was concentrated
2. additiondiluted with DCM
3. dry with materialThe organic layer was dried over sodium sulphate
4. concentrationconcentrated
5. customto afford the crude product
6. customPurification by column chromatography on silica gel (3% methanol in chloroform)