反应详情

To a solution of 7-Benzyloxy-3-hydroxymethyl-2-methyl-4-(5-methyl-chroman-6-yl)-2H-isoquinolin-1-one (3.5 g, 7.93 mmol) in dichloromethane (100 ml) was added manganese dioxide (6.89 g, 79.3 mmol). The resultant mixture was stirred at 70° C. under N2 for 2 h. The reaction mixture was filtered and concentrated to dryness to afford the title product (3.0 g, 86%).

1. filtrationThe reaction mixture was filtered
2. concentrationconcentrated to dryness