Lithium Hydroxide → HCID 60142091, compound

Participants

Reaction Steps

To a solution of tert-Butoxy-[7-(2-hydroxy-ethoxy)-2-methyl-4-(5-methyl-chroman-6-yl)-1-oxo-1,2-dihydro-isoquinolin-3-yl]-acetic acid methyl ester (30 mg, 0.059 mmol) in THF (3 ml), was added 1N LiOH (3 mL). The resultant mixture was stirred at 70° C. overnight. The solvent was removed in vacuo; the reaction mixture was acidified by 1N HCl solution to pH 5-6. The white solid was filtered to afford the title product (9 mg, 30.8%). LCMS (10-80 AB—2MIN.M): Rt=1.190, purity=97.3%, M+1=496.

Provenance & Evidence