HCID 68295707, compound → HCID 68295789, compound

Participants

Reaction Steps

A mixture of 2-(8-fluoro-5-methylchroman-6-carbonyl)benzoic acid (673 mg, 2.141 mmol) in acetic Acid (15 mL) was treated with Pd/C (60.0 mg) and the mixture was stirred under 50 psi of hydrogen at 65° C. until the reaction was judged complete by LCMS. The mixture was filtered over Celite and the filtrate was concentrated to give the title compound as a white solid: 1H NMR (400 MHz, DMSO-d6) δ ppm 1.80-2.05 (m, 5 H), 2.63 (t, J=6.44 Hz, 2 H), 3.95-4.15 (m, 2 H), 4.24 (s, 2 H), 6.57 (d, J=12.29 Hz, 1 H), 6.95 (d, J=7.61 Hz, 1 H), 7.21-7.34 (m, 1 H), 7.42 (td, J=7.56, 1.27 Hz, 1 H), 7.81 (dd, J=7.71, 1.07 Hz, 1 H), 12.92 (br. s., 1H); LC/MS (m/z) ES+=301 (M+1).

Provenance & Evidence