Lithium Hydroxide → HCID 68294980, compound

Participants

Reaction Steps

A mixture of methyl 4-(2,4-dimethylphenyl)-2-methyl-1-oxo-1,2-dihydroisoquinoline-3-carboxylate (30 g, 74.7 mmol) in tetrahydrofuran (THF) (400 mL) was treated with lithium hydroxide (8.94 g, 373 mmol) and stirred at reflux overnight. The mixture was concentrated and used crude in the next step (21.6 g, 94%). 1H NMR (400 MHz, DMSO-d6) δ ppm 13.81-14.14 (m, 1 H) 8.28-8.37 (m, 1 H) 7.62-7.69 (m, 1 H) 7.53-7.61 (m, 1 H) 7.13-7.19 (m, 1 H) 7.01-7.12 (m, 2 H) 6.82-6.91 (m, 1 H) 3.52 (s, 3 H) 2.34 (s, 3 H) 1.97 (s, 3 H); LC/MS (m/z) ES+=308 (M+1).

Provenance & Evidence