HCID 68295261, compound → HCID 68295055, compound

Participants

Reaction Steps

A solution of 2-(4-(2,4-dimethylphenyl)-2-methyl-1-oxo-1,2-dihydroisoquinolin-3-yl)pent-4-enoic acid (69 mg, 0.162 mmol,) in ethyl acetate (2 mL) was treated with platinum(IV) oxide (8.12 mg, 0.036 mmol) and the mixture was stirred at room temperature under an atmosphere of H2 for 1 hour. The mixture was filtered and the filtrate was purified by reverse phase hplc afford the title compound (31 mg, 52%). 1H NMR (400 MHz, CHLOROFORM-d) δ ppm 8.45-8.52 (m, 1 H) 7.43-7.54 (m, 2 H) 7.07-7.23 (m, 2 H) 6.97-7.03 (m, 1 H) 6.81-6.92 (m, 1 H) 3.79-3.97 (m, 1 H) 3.59 (s, 3 H) 2.42 (s, 3 H) 1.94-2.10 (m, 3 H) 1.54-1.74 (m, 2 H) 1.19-1.30 (m, 2 H) 0.72-0.88 (m, 3 H). LC/MS (m/z) ES+=364 (M+1).

Provenance & Evidence