Methylamine → HCID 20121408, compound

Participants

Reaction Steps

A solution of 4-cyano-2-fluoro-benzylbromide (15 g, 0.07 mol) in dry THF (50 mL) was added to the 40% aqueous solution of methyl amine (400 mL) at 5-10° C. and allowed to stir for 5 min. The mixture was extracted with DCM and the organic layer was dried over Na2SO4 and concentrated under vacuum, affording the title compound as a brown liquid (10 g, 89%). 1H NMR (DMSO-d6, 400 MHz) δ 7.77 (m, 1H), 7.68-7.61 (m, 2H), 3.71 (s, 2H), 2.24 (s, 3H).

Provenance & Evidence