HCID 140606942, compound → HCID 86683836, compound

Participants

Reaction Conditions

Reaction Steps

In a round bottom flask (500 ml), put under nitrogen atmosphere, tert-butyl [(1R)-1-(4-{(Z)-amino[({[2′-methyl-2-(trifluoromethyl)biphenyl-4-yl]carbonyl}oxy)imino]methyl}phenyl)ethyl]carbamate (17 g; 31.39 mmol; 1.0 eq.) was suspended in toluene (170 ml), and then heated at 100° C. After one night, the reaction mixture was concentrated under reduced pressure to give the title compound as a pale yellow oil (19.06 g, quantitative yield). This compound was used in the next step without further purification. LC/MS (Method B): 582.4 (M+AcO)−. HPLC (Method A) Rt 6.57 min (Purity: 99.1%)

Provenance & Evidence