tert-Butyl bromoacetate → HCID 66653116, compound

Participants

Reaction Steps

Tert-butyl N-[1-(4-{5-[2-methyl-2′-(trifluoromethyl)biphenyl-4-yl]-1,2,4-oxadiazol-3-yl}phenyl)ethyl]glycinate was prepared following the general procedure 11 starting from 1-(4-{5-[2-methyl-2′-(trifluoromethyl)biphenyl-4-yl]-1,2,4-oxadiazol-3-yl}phenyl)ethanamine, hydrochloride salt and tert-butyl bromoacetate. It was hydrolyzed following general procedure 8, affording the title compound as a white powder. 1H NMR: (DMSO-d6, 300 MHz) δ 8.18 (m, 3H), 8.08 (m, 1H), 7.91 (d, J=7.90 Hz, 1H), 7.77 (m, 3H), 7.69 (m, 1H), 7.41 (m, 2H), 4.74 (m, 1H), 3.74 (m, 1H), 3.52 (m, 1H), 2.11 (s, 3H), 1.61 (d, J=6.8 Hz, 3H). LC/MS (Method B): 482.2 (M+H)+, 480.2 (M−H)−. HPLC (Method A) Rt 4.25 min (Purity: 99.9%).

Provenance & Evidence