Hydrochloric Acid → HCID 68064146, compound

Participants

Reaction Conditions

Reaction Steps

To tert-butyl N-[2-hydroxy-1-(4-{5-[2′-methyl-2-(trifluoromethyl)biphenyl-4-yl]-1,2,4-oxadiazol-3-yl}phenyl)ethyl]glycinate (0.200 g; 0.13 mmol) was added HCl solution in dioxane (4 M; 4 mL) and the reaction mixture stirred 80° C. for 1 hour. The reaction mixture was allowed to cool and the solvent evaporated in vacuo. The residue was purified by preparative HPLC to afford the title compound. 1H NMR: (CDCl3, 400 MHz) δ 8.57 (1H, d, J=1.2 Hz), 8.54-8.52 (1H, m), 8.14 (2H, d, J=8 Hz), 7.70 (1H, d, J=8 Hz), 7.63 (2H, d, J=8.4 Hz), 7.44-7.38 (2H, m), 7.34-7.30 (1H, m), 7.21-7.20 (1H, m), 3.94-3.91 (1H, m), 3.65-3.56 (1H, m), 3.52-3.47 (1H, m), 3.20 (1H, d, J=16.8 Hz), 3.06 (1H, d, J=16.8 Hz), 2.06 (3H, s). LC/MS (Method B): 496 (M+H)+. HPLC (Method D) Rt 3.04 min (Purity: 94.9%).

Provenance & Evidence