反应详情

温度

60 °C

4-cyano-3-(2,4-dichlorophenyl)-5-(methylsulfonyl)thiophene-2-carboxamide (0.013 g, 0.0346 mmol) was dissolved in 2-hydroxymethylmorpholine (0.300 g, 2.56 mmol) and the solution was heated at 60° C. overnight. The residue was concentrated in vacuo and column chromatography was performed and yielded the title compound 87 (0.010 g, 66%) as a white solid. LCMS: (FA) ES+ 412, 414, 416. 1H NMR (400 MHz, d4-methanol) δ: 7.68 (s, 1H), 7.50 (d, 1H), 7.40 (d, 1H), 4.08-3.92 (m, 3H), 3.88-3.56 (m, 4H), 3.16-3.04 (m, 2H).

1. concentrationThe residue was concentrated in vacuo and column chromatography