Hydrochloric Acid → HCID 71466164, compound

Participants

Reaction Steps

Tert-butyl-4-(3-(6-(4-fluoro-3-methoxybenzylcarbamoyl)-2-methylpyrimidin-4-yl)-4,5-dihydroisoxazol-5-yl)piperidine-1-carboxylate (0.3 g, 0.569 mmol, G.1.18) was dissolved in 4N 1,4-dioxane.HCl (5 mL) and stirred at RT for about 1 h. Excess solvent was removed in vacuo and the crude material was triturated with ether (2×10 mL) to afford N-(4-fluoro-3-methoxybenzyl)-2-methyl-6-(5-(piperidin-4-yl)-4,5-dihydroisoxazol-3-yl)pyrimidine-4-carboxamide hydrochloride as a white solid 0.2 g (82%). LC/MS (Table 1, method e) Rt=2.53 min; MS m/z 428.3 (M+H)+.

Provenance & Evidence