HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 2-(5-Amino-3-methyl-1H-pyrazol-4-yl)-5-fluoro-benzothiazole-6-sulfonic acid amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | HCID 178434665 | HCID 178434665 | — |
| Reactant | HCID 178434669 | HCID 178434669 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 2-(5-Amino-3-methyl-1H-pyrazol-4-yl)-5-fluoro-benzothiazole-6-sulfonic acid amide | HCID 178434666 | 25% |
Reaction Steps
The title compound (30 mg) was prepared in two steps from crude 2-(5-amino-3-methyl-1H-pyrazol-4-yl)-5-fluorobenzothiazole-6-sulfonic acid, which had been derived from the chlorosulfonation of 90 mg of 4-(5-fluorobenzothiazol-2-yl)-5-methyl-2H-pyrazol-3-ylamine, and a solution of excess ammonia dissolved in ethanol. MS (m/z, ES+): 328.0 (M+1,100%). Yield=25%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09434720B2 |
| Source dataset | uspto-grants-2016_09 |
| ORD ID | ord-7859da01217c41d1aa290302a0cfdcc6 |
| Source note | uspto-grants-2016_09 |