Water → HCID 67300552, compound

Participants

Reaction Conditions

Reaction Steps

Cyclopentane-1,3-diylbis(methylene)bis(4-methylbenzenesulfonate) 1-21 (1 equivalent) was taken in DMF:H2O mixture (3:1) and sodium cyanide (6 equivalents) was added and stirred at 150° C. for 15 h. The progress of the reaction was monitored by TLC. After completion of the reaction, reaction mixture was quenched with water, extracted with diethyl ether. The organic layer was washed with brine, dried over anhydrous sodium sulfate and evaporated under reduced pressure. The crude product was purified to afford the desired product I-22.

Provenance & Evidence