Water → (2-Fluoro-5-methoxyphenyl)acetic acid

HRID 572932Notes

Reaction equation

HRID 572932 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][CH3:9])=[CH:4][C:3]=1[CH2:10][C:11]#N.[OH-:13].[Na+].[OH2:15]>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][CH3:9])=[CH:4][C:3]=1[CH2:10][C:11]([OH:15])=[O:13]

Participants

4

Reactant 3

HCID 962WaterHCID 14798Sodium HydroxideHCID 23074300(2-Fluoro-5-methoxyphenyl)acetonitrile

Product 1

HCID 21034868(2-Fluoro-5-methoxyphenyl)acetic acid

Procedure

The solution of 2-(2-fluoro-5-methoxyphenyl)acetonitrile (200 mg, 1.0 mmol) and sodium hydroxide (81.5 mg, 2.0 mmol) in water was stirred at 100 degree for 8 h. The reaction mixture was evaporated under reduced pressure to get the crude product for the next step without further purification. LC-MS: m/z (M−H)=183.2

Workup

  1. customThe reaction mixture was evaporated under reduced pressure

Sources & evidence

ORD record
ord-4a72784b06bd497fbf1c3d8e5225b640
Source dataset
uspto-grants-2015_05
Patent number
US09029531B2

Reaction notes

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